Faculty Profile: La Spada, Albert

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Faculty Information Lab Information (Packet Type, Course Title, & Department) Location
La Spada, Albert
Lab Contact:
Al La Spada
alaspada@uci.edu
A NEURODEGENERATION
Department: Pathology
ISEB building -- 2nd floor

Research Description

Dr. La Spada's research is focused upon neurodegenerative disease, and he is seeking the molecular events that underlie neurodegeneration and neuron cell death in spinal & bulbar muscular atrophy (SBMA), spinocerebellar ataxia type 7 (SCA7), Huntington’s Disease, ALS, Parkinson’s disease, and Alzheimer's disease. He and his team have uncovered evidence for transcription dysregulation, perturbed bioenergetics, and altered protein quality control as contributing factors to neuron dysfunction. By reproducing molecular pathology in mice and in neurons derived from human patient stem cells, Dr. La Spada has begun to develop therapies to treat these disorders intended to boost the function of pathways of CNS homeostasis that decline with aging.

Requirements to Participate

Students should be willing to work a minimum of 10 hours / week.
We require a commitment of at least one year.

1) Background in physical sciences and biological sciences, including introductory chemistry and biology
2) Experience in lab research through college-level coursework with labs, or experience working in a biomedical, physical sciences, or engineering research lab
3) Anticipate a possible future career in the biomedical sciences or in healthcare.

Faculty Means of Evaluation

Attendance: 20 Pts (working assigned hours, being on time)
Lab Work: 40 Pts (quality, accuracy, integrated.synthesis of information and safety)
Communication: 20 Pts (Written/Oral reports, questions and discussion with mentor)
Lab citizenship: 20 Pts (organization, clean up and follow through)
Total: 100 points