Faculty Profile: Cotman, Carl

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Faculty Information Lab Information (Packet Type, Course Title, & Department) Location
Cotman, Carl
Lab Contact:
Carl Cotman
cwcotman@uci.edu
(949) 824-5847
A NEUROCHEMISTRY
Department: Neurobiology & Behavior
1113 Gillespie Neuroscience Research Facility

Research Description

Our current research focuses on biochemical and physiological mechanisms of synaptic plasticity, a cellular correlate of learning and memory that generates a long-lasting strengthening of synaptic transmission. Specifically, our work aims to dissect molecular pathways involved in synaptic dysfunction in aging and Alzheimer’s disease with the ultimate goal of finding therapeutic strategies to prevent brain impairment. The student must be interested in laboratory research, which will include techniques such as Western blotting, immunofluorescence and flow cytometry on isolated synaptic terminals from brain tissue. The student will learn a novel method that we develop to study synaptic plasticity at the single-synapse level. Using this novel method the student will test multiple compounds to see if they can boost synaptic plasticity. Parallel studies involving human brain tissue (Alzheimer's disease and normal aged controls) will also be included as the student acquires the necessary skills.