Faculty Profile: Mander, Bryce A

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Faculty Information Lab Information (Packet Type, Course Title, & Department) Location
Mander, Bryce A
Lab Contact:
Bryce Mander
Department: Psychiatry and Human Behavior
UCI Health Sleep Center; 20350 SW Birch St.

Research Description

Addressing the epidemic of Alzheimer's disease (AD) is a critical priority, but it remains unclear which factors promote the accumulation of AD pathology, and which determine the vulnerability of the brain to their accumulation. Such understanding would aid interventions to prevent AD onset and slow its progression. Sleep disturbance and sleep disorders increase AD risk, but the underlying mechanisms remain unclear. Recent studies show that sleep deprivation and targeted suppression of slow wave activity (SWA) during sleep increase accumulation of cerebrospinal fluid markers of next day β-amyloid (Aβ) and tau pathology, the defining pathologies of AD. Our recent work demonstrated that local deficits in SWA are also associated with cortical Aβ plaque burden. Other findings indicate that excessive daytime sleepiness predicts cortical Aβ accumulation over two years, but the underlying mechanism(s) of this effect remains unclear. We have recently shown that Aβ-related sleep disturbance predicts hippocampus hyperactivation and memory impairment in healthy older adults, two core preclinical features of AD-related cognitive decline. The research objective is to clarify which aspects of sleep disturbance predict AD pathological accumulation and spread, and which track longitudinal change in medial temporal lobe (MTL) dysfunction and degeneration.
Aim 1: Determine which measures of sleep disturbance (poor sleep efficiency, reduced total sleep time, excessive daytime sleepiness, or local deficits in slow waves, sleep spindles, their coupling, or REM sleep desynchrony) are associated with cortical Aβ and MTL tau accumulation and spread over two years in healthy older adults
Aim 2: Determine which measures of sleep disturbance, after controlling for Aβ and tau, relate to early, AD-relevant measures of MTL dysfunction and degeneration in healthy older adults, e.g. increased hyperactivation within hippocampal subfields cornu ammonis region 3 and the dentate gyrus (CA3/DG) during memory retrieval, entorhinal cortical (EC) atrophy, perforant path degeneration, and episodic memory decline.
The long-term goal of this research program is to utilize the findings from the proposed projects to determine which sleep-based biomarkers of AD risk are prodromes of AD pathogenesis, and to determine if mechanism-targeted sleep-based therapeutic interventions decrease cognitive decline in older adults, slow AD progression, and delay AD conversion.

Role of 199 Students in project: Students will aid in screening and consenting subjects on this project, as well as data collection, including collection of high density EEG data, cognitive task data, and questionnaire data. Students will also aid in data entry where necessary, and analysis of findings. Students will also aid with other sleep-related projects when necessary, though their primary responsibility will be to projects related to sleep in the context of aging and Alzheimer's disease. Students will be required to periodically present either findings directly related to their work responsibilities or relevant journal articles at regular lab meetings.

Requirements to Participate

Interest in human subject neuroscience research, willingness to complete required human subjects IRB training, willing to commit to at least 1 year as a research assistant, willing to work at late and early hours on both weekdays or weekends due to the demands of sleep studies, willing to help collect data as well as analyze it. Primary interest in sleep research is encouraged but not required. 3 - 4 hours per unit.

1 year Commitment.

Faculty Means of Evaluation

Attendance: 30Pts (working assigned hours, being on time)
Lab Work: 50Pts (quality, accuracy, attention to detail, integrated synthesis of information and safety, completion of assigned projects)
Communication: 20Pts (Written/Oral reports, journal club presentations of articles or data, questions and discussion with mentor)
Total: 100 points