Faculty Profile: Benavente, Claudia

Return to Faculty Sponsors

Faculty Information Lab Information (Packet Type, Course Title, & Department) Location
Benavente, Claudia
Lab Contact:
Claudia Benavente
claudia.benavente@uci.edu
949-824-7845
A CANCER EPIGENETICS
Department: Pharmaceutical Sciences
Sprague Hall B200

Research Description

The Benavente Lab research interests focus on understanding pediatric solid tumors and contributing to their targeted therapeutics. Our research aims to understand the chromatin remodeling processes that establish the normal epigenetic landscape in developing tissue, how it can be perturbed to promote carcinogenesis, and provide insight for the development of new therapies. Through the study of the epigenetic landscape of retinoblastoma and osteosarcoma, our laboratory hopes to determine why some cell types are more susceptible to tumor formation than other cell types, in particular following RB1 inactivation. We aim to elucidate the role of epigenetics and genome instability in tumorigenesis and how the RB/E2F pathway participates in this process. The use of integrative analyses to study the changes in chromatin organization and gene expression that occur during tumorigenesis will help us identify potential novel therapeutic targets for anticancer treatment.

Time Commitment per Week

3 - 4 hours per unit. 2 year commitment. Minimum 4 units.

Faculty Means of Evaluation

Attendance: 20 Pts. Lab Work: 40 Pts. Communication: 20 Pts. Lab citizenship: 20 Pts. Total: 100 Pts.