Faculty Profile: Inlay, Matthew

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Faculty Information Lab Information (Packet Type, Course Title, & Department) Location
Inlay, Matthew
Lab Contact:
Matthew Inlay
minlay@uci.edu
A HEMATOPOIESIS
Department: Molecular Biology & Biochemistry
1100 Gross Hall

Research Description

My lab’s research interests span Developmental Biology, Stem Cell Biology, and Immunology. My primary research focus is on the developmental origins of the stem cell that gives rise to all blood and immune cells, called the hematopoietic stem cell (HSC). We use mouse models to identify precursors to HSCs in the developing embryo, when and where they arise, and the external signals and gene expression programs that regulate HSC emergence. The techniques we employ include fluorescence-activated cell sorting (FACS), fluorescent microscopy, live and time-lapse imaging, mouse embryo culture, and transplantation into immunodeficient recipient mice. We hope to use this information to aid efforts to generate functional HSCs from human pluripotent stem cell lines (PSCs) to treat human blood diseases and disorders. A portion of my lab works with human PSC lines to differentiate these cells to hematopoietic lineages in culture to apply the concepts we learn in the mouse. A secondary focus of lab is on the developmental origin of microglia, which are the primary immune cell of the central nervous system. In this context, we are interested in which cells and tissues in the embryo produce microglia, and what role microglial dysfunction plays in neurodegenerative disease, such as Alzheimer’s Disease. We are identifying novel biomarkers for microglia to examine their function in mouse and human samples. Students who perform Bio199 sections in my lab will be expected to commit to over one year (preferably 2+ years) of research in the lab, and dedicate at least 10 hours per week of study. Students who can also commit to research over the summer are also preferred. A GPA above 3.0 is required, but higher GPAs are preferred. Freshmen and sophomores with strong academic records are particularly encouraged to apply. In order to be accepted into the lab, prospective students will need to be sponsored by a full time lab member (grad student or post-doc), who will agree to mentor the student. Thus, prospective students will need to first meet with me and my full time lab members.

Time Commitment per Week

3 - 4 hours per unit. 2 year commitment. Minimum 3 units.

Faculty Means of Evaluation

Attendance, work ethic, and attitude.