Faculty Profile: Qiao, Feng

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Faculty Information Lab Information (Packet Type, Course Title, & Department) Location
Qiao, Feng
Lab Contact:
Feng Qiao
qiao@uci.edu
(949) 824-0159
A TELOMERE BIOLOGY
Department: SOM - Biological Chemistry
Hitachi 121 & 122.

Research Description

Telomeres & telomerase and their roles in cancer and stem cell diseases; Structural, biochemical and molecular genetic analyses of nucleoprotein assemblies Telomeres are closely involved in stem cell differentiation and cancer cell proliferation. Our long-term goal is to reveal new mechanisms for telomere length regulation and chromosome end protection. Therefore, valuable targets for mechanism-driven design of cancer and anti-aging therapeutics may be identified through our research. Specifically, we are interested in: ? Regulation of telomere homeostasis from atomic level to system level using the integration of biochemistry, structural biology (especially, x-ray crystallography), and genetics approaches. ? Re-engineering/re-wiring telomere regulatory pathways using synthetic biology modules and concepts. ? Chemical biology approach to identify small molecules that can inhibit telomere ON/OFF transition thereby inhibiting cancer cell progression

Requirements to Participate

Weekly Group meetings COURSE COMPLETION: 3-5 page research progress report.

Time Commitment per Week

3-4 hours per unit

Faculty Means of Evaluation

Research Performance and Research Report.