Faculty Profile: Qiao, Feng
|Faculty Information||Lab Information (Packet Type, Course Title, & Department)||Location|
Department: SOM - Biological Chemistry
|Hitachi 121 & 122.|
Telomeres & telomerase and their roles in cancer and stem cell diseases; Structural, biochemical and molecular genetic analyses of nucleoprotein assemblies Telomeres are closely involved in stem cell differentiation and cancer cell proliferation. Our long-term goal is to reveal new mechanisms for telomere length regulation and chromosome end protection. Therefore, valuable targets for mechanism-driven design of cancer and anti-aging therapeutics may be identified through our research. Specifically, we are interested in: ? Regulation of telomere homeostasis from atomic level to system level using the integration of biochemistry, structural biology (especially, x-ray crystallography), and genetics approaches. ? Re-engineering/re-wiring telomere regulatory pathways using synthetic biology modules and concepts. ? Chemical biology approach to identify small molecules that can inhibit telomere ON/OFF transition thereby inhibiting cancer cell progression
Requirements to Participate
Weekly Group meetings COURSE COMPLETION: 3-5 page research progress report.
Time Commitment per Week
3-4 hours per unit
Faculty Means of Evaluation
Research Performance and Research Report.