Faculty Profile: McClelland, Michael

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Faculty Information Lab Information (Packet Type, Course Title, & Department) Location
McClelland, Michael
Lab Contact:
Michael Mcclelland
mmcclell@uci.edu
A CANCER BACTERIA
Department: SOM - Microbiology & Molecular Genetics
Medical Surge 1, Building 810

Research Description

Three possible areas for projects:

(1) We are studying the role of the normal tissue (stroma) surrounding prostate cancer. This stroma may be important in supporting the tumor, and may contribute the chance of the tumor becoming metastatic. There appears to be differences in the stroma that distinguish most African Americans from European Americans. We are studying gene expression and DNA methylation to identify genes that might be prognostic in each race, and those genes that might be most useful in all races. We are investigating the possible mechanisms of such genes in cancer.

(2) We use comparative genome sequencing and high-throughput screening of bacterial mutants to study the life cycle of the pathogen Salmonella as a model of bacterial infectious disease, including various environmental, ecological, and food safety niches.

(3) We are studying the behavior of bacteria that naturally accumulate in tumors and may be used as delivery agents for cancer therapeutics.

LEARNING: Each student will engage in research adapted to fit their background and/or interest either by bench work or by using computational analysis, or both. Projects will subsequently expand to fit the growing capabilities of the student in any of a variety of areas including, but not limited to, PCR, RNA-seq, DNA polymorphisms, population biology, mutant constructions, writing of algorithms for data analysis. Students that dedicate at least a year to their research project may have done enough work to obtain authorship on a published peer-reviewed scientific paper.

Links to recent papers: https://scholar.google.com/citations?hl=en&user=65Wel8MAAAAJ&view_op=list_works&sortby=pubdate

Requirements to Participate

3 - 4 hours per unit. 1 year Commitment.

Minimum 3 units. Second or third year students, who may continue in the lab until graduation. At least one A grade in a University level Mathematics, Statistics, Computer Science or similar course. Each quarter students will turn in a 2 page summary of work completed. This can include background information obtained by reading the literature, details about a technique learned, and/or data generated.

Faculty Means of Evaluation

Safety, effort, etiquette, and clear, complete, and accurate records of all results, including any errors that occurred. Later quarters assess common sense, independence, initiative, and critical thinking. You can get an A by being outstanding in any one area of laboratory research or by being excellent in most areas.